Nicoletta Resta Selected Research

Proteus Syndrome

1/2021	Clinical experience with the AKT1 inhibitor miransertib in two children with PIK3CA-related overgrowth syndrome.
1/2019	First evidence of a therapeutic effect of miransertib in a teenager with Proteus syndrome and ovarian carcinoma.
1/2018	In vitro efficacy of ARQ 092, an allosteric AKT inhibitor, on primary fibroblast cells derived from patients with PIK3CA-related overgrowth spectrum (PROS).

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Nicoletta Resta Research Topics

Disease

15	Neoplasms (Cancer) 12/2021 - 12/2004
4	Peutz-Jeghers Syndrome (Polyposis, Hamartomatous Intestinal) 02/2012 - 01/2005
3	Cardiomyopathies (Cardiomyopathy) 12/2021 - 12/2020
3	Proteus Syndrome 01/2021 - 01/2018
2	Ventricular Tachycardia 09/2021 - 12/2020
2	Rare Diseases (Rare Disease) 01/2021 - 01/2019
2	Muscle Hypotonia (Hypotonia) 12/2020 - 01/2018
2	Hyperplasia 01/2019 - 11/2015
2	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2015 - 10/2004
1	Pathologic Constriction (Stenosis) 09/2021
1	Diabetes Mellitus 07/2021
1	Hyphema 05/2021
1	Hemimegalencephaly 01/2021
1	Congenital Heart Defects (Congenital Heart Defect) 01/2021
1	Lipomatosis 01/2021
1	Ventricular Fibrillation 12/2020
1	Dystonia (Limb Dystonia) 12/2020
1	Congenital Myasthenic Syndromes (Myasthenia Gravis, Congenital) 12/2020
1	Respiratory Insufficiency (Respiratory Failure) 12/2020
1	Gastric Polyposis 01/2020
1	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 01/2020
1	Adenoma (Adenomas) 01/2020
1	Aggressive Fibromatosis (Desmoid) 01/2020
1	Brugada Syndrome 10/2019
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2019
1	Carcinoma (Carcinomatosis) 01/2019
1	Cognitive Dysfunction 01/2019
1	Clubfoot (Talipes Equinovarus) 01/2018
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2018
1	Congenital Abnormalities (Deformity) 01/2018
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 02/2016
1	Sarcoma (Soft Tissue Sarcoma) 02/2016
1	Carcinogenesis 11/2015
1	Mitochondrial Diseases (Mitochondrial Disease) 02/2015
1	Arrhythmogenic Right Ventricular Dysplasia (Arrhythmogenic Right Ventricular Cardiomyopathy) 01/2015
1	Laminopathies 01/2015
1	Colorectal Neoplasms (Colorectal Cancer) 12/2012
1	Multiple Hamartoma Syndrome (Cowden's Disease) 03/2012
1	Autistic Disorder (Autism) 03/2012
1	Megalencephaly 03/2012
1	Epilepsy (Aura) 03/2012
1	Hamartoma 02/2012
1	Ganglioglioma 11/2008
1	Papillary Thyroid Cancer 12/2007
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2006
1	Polyps 07/2006
1	Angiodysplasia 02/2006
1	Telangiectasis (Telangiectasia) 02/2006
1	Brain Stem Infarctions (Weber Syndrome) 02/2006
1	Heart Failure 10/2004

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 12/2020 - 10/2014
4	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 02/2012 - 12/2004
3	Lamin Type A (Lamin A)IBA 12/2021 - 01/2015
3	MiransertibIBA 01/2021 - 01/2018
2	Therapeutic UsesIBA 01/2021 - 01/2019
2	Nonsense Codon (Nonsense Mutation)IBA 10/2019 - 10/2006
2	Protein Isoforms (Isoforms)IBA 01/2019 - 11/2008
2	RNA Splice SitesIBA 09/2006 - 01/2005
1	Biological ProductsIBA 12/2021
1	AntibodiesIBA 07/2021
1	Fluorescein (Funduscein)FDA LinkGeneric 05/2021
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021
1	Cytidine Monophosphate (CMP)IBA 12/2020
1	GadoliniumIBA 12/2020
1	CollagenIBA 12/2020
1	AcetylcholinesteraseIBA 12/2020
1	Amino Acids FDA Link 01/2020
1	Codon (Codons)IBA 01/2020
1	Sirolimus (Rapamycin)FDA Link 01/2019
1	apo-dystrophin 1IBA 01/2019
1	DystrophinIBA 01/2019
1	AntioxidantsIBA 01/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018
1	NestinIBA 05/2017
1	Tyrosine Kinase InhibitorsIBA 02/2016
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 02/2016
1	p38 Mitogen-Activated Protein KinasesIBA 11/2015
1	coenzyme Q10 (CoQ10)IBA 02/2015
1	Monoclonal AntibodiesIBA 12/2012
1	TensinsIBA 03/2012
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 03/2012
1	Calcibiotic Root Canal SealerIBA 06/2011
1	RNA (Ribonucleic Acid)IBA 11/2008
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 12/2007
1	Tyrosine (L-Tyrosine)FDA Link 12/2007
1	Phosphotransferases (Kinase)IBA 12/2007
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 12/2007
1	NucleotidesIBA 09/2006
1	EndoglinIBA 02/2006
1	beta Adrenergic ReceptorsIBA 10/2004
1	Adrenergic Agents (Adrenergic Drugs)IBA 10/2004

Therapy/Procedure

5	Therapeutics 01/2021 - 12/2012
2	Artificial Respiration (Mechanical Ventilation) 12/2020 - 01/2018
1	Drug-Eluting Stents 09/2021
1	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 12/2020
1	Precision Medicine 01/2019
1	Lasers (Laser) 05/2017
1	Ligation 11/2011
1	Heart Transplantation (Grafting, Heart) 10/2004